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Intestinal Permeability Protocol

Intestinal permeability (IP) is characterized physiologically by loss of intestinal barrier function through deregulation of tight junctions, pathogenic infection, degradation of the mucus layer, increased paracellular transport, enterocyte apoptosis, and/or transcellular permeability. This impaired function allows macromolecules, pathogens, and other microorganisms to traverse the epithelial layer and enter the submucosa, triggering a pro‑inflammatory state and immune response within the gut‑associated lymphoid tissue (GALT).

Eat Well, Live Well: Your Path to Wellness

  • Try avoiding foods that contain gluten, casein, and other proteins that can make gut permeability issues worse. These proteins are found in foods like wheat and dairy products, and cutting them out of your diet might help improve your symptoms.
  • You might also consider trying a broader elimination diet that excludes other common triggers like soy, corn, and eggs. Remove these foods from your diet for 21 days, and then reintroduce them one at a time, every fourth day, to see if any specific food causes symptoms.
  • Keep track of how different foods affect your symptoms using a tool like the Well World “Condition Tracker.” This can help you identify what exacerbates your condition and what doesn’t.
  • Explore a diet that’s gentle on your digestive system, such as the specific-carbohydrate diet or the GAPS diet. These diets limit foods that are hard to digest, giving your gut a chance to heal.
  • Try to reduce or avoid things that can irritate your gut, including alcohol, caffeine, and medications like non-steroidal anti-inflammatory drugs (NSAIDs).
  • Incorporate more vegetable and bone broths into your meals. They’re known to support the lining of your gut, which can be particularly helpful if you’re dealing with permeability issues.

Our Premium Supplements for Optimal Health

GI Revive™: GI ReviveTM is a synergistic formula offering comprehensive support for optimal gastrointestinal health and function. It provides targeted levels of nutrients that support the natural repair of gastrointestinal mucosa and help support a healthy inflammatory response along with ingredients to promote intestinal regularity.*

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IgGI Shield™: IgGI Shield™ combines ImmunoLin® with N‑acetyl‑D‑glucosamine to support the structure of the cells of the intestinal lining and to promote a healthy inflammatory response in the cells of the gastrointestinal (GI) tract.* These ingredients work together to provide support to the intestinal barrier and to support gut immune health.* ImmunoLin®, a serum‑derived bovine immunoglobulin concentrate (SBI), is the only purified, dairy‑free source of immunoglobulin G (IgG) available as a dietary supplement. Immunoglobulins play an integral role in the support of healthy immune function at the gut and systemic levels.* N‑acetyl‑D‑glucosamine promotes healthy immune function by promoting a balanced immune response.*

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ProbioMed™ 100: ProbioMed™ 100 is a high potency, shelf stable, dairy‑free probiotics formulation containing 100 billion CFU per serving. It consists of 10 of the most highly‑researched probiotic strains, with each strain and specific CFU count being fully disclosed. These are robust strains that are capable of surviving the harsh journey to the intestines and are able to attach to the intestinal walls, where they can grow and function effectively to support GI health.*

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L‑Glutamine Powder: L‑Glutamine powder supplies the amino acid L‑glutamine, which is essential for the health of the immune system and the digestive tract. In the gut, it promotes the health and function of the mucosal cells for normal healing and repair.*

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OmegAvail™ Liquid: OmegAvail™ Liquid is a high potency EPA (725 mg) and DHA (425 mg) formula. Its liquid form makes it easy to titrate and is a great choice for children and those who prefer not to swallow pills.

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Why Trust DeNovo’s Recommendations?

DeNovo’s selection process for supplements goes beyond mere effectiveness. We seek partnerships with manufacturers that share our commitment to quality, transparency, and ethical practices. By choosing supplements endorsed by DeNovo, you’re not just purchasing a product; you’re investing in a vetted solution that’s part of a holistic approach to health and wellness.

DeNovo’s dedication to your health extends to every recommendation we make, ensuring that you receive the best possible care and support on your path to wellness.